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Optimization of Repetitive Transcranial Magnetic Stimulation Targets Based on Brain Network Connectivity and Its Effects on Motor Recovery in Parkinson's Disease Patients

Optimization of Repetitive Transcranial Magnetic Stimulation Targets Based on Brain Network Connectivity and Its Effects on Motor Recovery in Parkinson's Disease Patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500101816
Enrollment
Unknown
Registered
2025-04-30
Start date
2025-05-01
Completion date
Unknown
Last updated
2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

Intervention Group:Lumbosacral dorsal root nerve repetitive magnetic stimulation therapy, Stimulation parameters were initially set at 10 Hz frequency, with intensity at 120% of motor threshold, admin
Control Group:Except for the vertical placement of the coil, other parameter settings and treatment regimens were exactly the same as those in the experimental group.

Sponsors

Guangdong Sanjiu Brain Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age between 40 and 65 years; 2. Able to communicate effectively; 3. Capable of independent walking for more than 10m under supervision; 4. No significant visual impairment, no history of deep brain stimulation or other orthopedic/cardiac surgeries within the past year; 5. Approved by the hospital ethics committee, with patients or their families informed of the study purpose and having signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Non-primary Parkinson's disease such as vascular parkinsonism, parkinsonian syndromes, and Parkinson-plus syndromes; 2. Patients with cardiopulmonary insufficiency, neurological or musculoskeletal diseases that affect gait function; 3. Patients with contraindications to low-frequency electrical therapy, such as artificial ventilators, cardiac pacemakers, or metallic foreign bodies; 4. Patients with a history of epilepsy, concurrent tumors, or cancer.

Design outcomes

Primary

MeasureTime frame
Gait parameters;UPDRS Part III motor scores;

Countries

China

Contacts

Public ContactGuo Yongliang

Guangdong Sanjiu Brain Hospital

drguoyl@126.com+86 137 2514 2578

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026