Patients with severe acute brain injury and ARDS
Conditions
Interventions
Intervention group:Cevelestat sodium for injection
Sponsors
Changzhou Wujin People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age>=18 years and, <=75 years, gender is not limited; 2. Patients who are able to administer within 72 hours of the onset of ARDS; 3. Patients with any type of simple acute brain injury, including: structural brain injury with trauma; Structural brain injury without trauma (i.e., intracerebral hemorrhage, subarachnoid hemorrhage, or acute ischemic stroke); Non-structural brain injury (i.e., cardiac arrest or meningitis, etc.); 4. Confirmed diagnosis of acute respiratory distress syndrome according to the latest global diagnostic criteria for ARDS released by the American Thoracic Society International Conference (ATS 2023) in May 2023; 5. Doctors carry out routine treatment according to the patient's condition; 6. Study participants voluntarily sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Age3 weeks) and/or recent (within 5 days prior to screening) use of high-dose corticosteroids or immune support; 13. Combined with chronic respiratory diseases (including but not limited to chronic obstructive pulmonary disease, chronic emphysema, etc.) 14. Patients with coagulation dysfunction and intracranial tumors 15. Those who are judged by the investigator to be unsuitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lung function indicators;Markers of inflammation;Neurological indicators;Patient outcomes;Radiographic changes; | — |
Countries
China
Contacts
Public ContactCui Weiyan
Changzhou Wujin People's Hospital
Outcome results
None listed