Triple negative breast cancer
Conditions
Interventions
First cohort:None
Second cohort:None
Sponsors
Affiliated Jinling Hospital of Nanjing University School of Medicine (Eastern Theater General Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The age of the patient is 18~70 years old; 2. Confirmed diagnosis of advanced triple-negative breast cancer by pathological histology (immunohistochemistry detection ER negative, PR negative, HER2 negative or 1 (or HER2 immunohistochemistry 2 with FISH detection HER2 amplification negative); 3. The patient has received 2nd line or more treatment before; 4. The patient's ECOG score was =3 months; 5. Leukocyte >=4×10^9/L, hemoglobin >=100g/L, platelet >=80×10^9/L, serum liver enzyme is not higher than 2 times the upper limit of normal, serum creatinine level is not higher than the upper limit of normal, and cardiac enzyme spectrum is normal; 6. At least one lesion measurable by CT or MRI; 7. No history of other malignant tumors;
Exclusion criteria
Exclusion criteria: Only unmeasurable lesions, such as thoracic ascites, carcinomatous lymphangitis, diffuse liver invasion, bone metastases; Those with no measurable lesions or non-evaluable lesions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Progrssion Free Survival; | — |
Countries
China
Contacts
Public ContactGuichun Huang
Affiliated Jinling Hospital of Nanjing University School of Medicine (Eastern Theater General Hospital)
Outcome results
None listed