postpartum hemorrhage
Conditions
Interventions
1:Women with cicatricial uterus were injected intravenously with oxytocin at 2 U/h for 4h after cesarean section
2:Women with cicatricial uterus were injected intravenously with oxytocin at 2 U/h for 6h after cesarean section
3:Women with cicatricial uterus were injected intravenously with oxytocin at 2 U/h for 8h after cesarean section
4:After cesarean section in twin pregnant women, oxytocin was continuously pumped intravenously at 2 U/h for 4h
5:After cesarean section in twin pregnant women, oxytocin was continuously pumped intravenously at 2 U/h for 6h
6:After cesarean section in twin pregnant women, oxytocin was continuously pumped intravenously at 2 U/h for 8h
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
Female
Age
25 Years to 45 Years
Inclusion criteria
Inclusion criteria: From July 2024 to January 2026, 246 cases of twin pregnancies at or beyond 36 weeks and 246 cases of women with a history of cesarean section (scarred uterus) at or beyond 37 weeks who were registered at Peking University Third Hospital and underwent elective cesarean section under spinal anesthesia were included.
Exclusion criteria
Exclusion criteria: 1. Refuse to sign the informed consent; 2. Threatened labor or labor; 3. The presence of uterine contraction weakness and PPH risk factors (placental factors such as placenta previa, blood vessels previa, placenta implantation, etc.); Pregnancy hypertension, preeclampsia, eclampsia; Macrosomia; Hyperamniotic fluid; A history of uterine systole fatigue and PPH; Suffering from clotting disorders (abnormal clotting function, thrombocytopenia, etc.), liver, kidney or cardiovascular diseases, etc. 4. During the operation, if there is an increase in bleeding due to severe uterine atony or placental adhesion, incision extension and other factors, and the standard oxytocin protocol fails to induce effective uterine contractions to reduce bleeding, additional uterotonics or surgical procedures (such as uterine cavity packing, uterine artery ligation, B-Lynch suture, etc.) (judged by the surgeon) are required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postpartum blood loss in 24 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Preoperative and postoperative hemoglobin and hematocrit;Incidence of nausea, vomiting, headache, hypotension, tachycardia and other adverse reactions during oxytocin use;Incidence of use of additional uterine contractile agents; | — |
Countries
China
Contacts
Public ContactZhang Yan
Peking University Third Hospital
Outcome results
None listed