Helicobacter pylori infection
Conditions
Interventions
Group C: Healthy blank control group
Group A:Standard bismuth quadruple therapy, 2week
Group B :High dose group of fucoidan,2g/d,6week
Group D:Standard bismuth quadruple therapy 2week and fucoidan 2g/d 6week
Group E:Standard bismuth quadruple therapy 2week and probiotics 4week
Sponsors
Jilin Medical University,
Affililated Hospital of Jilin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 25 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-25 years old 2.Gender: Male or female, with equal proportions 3.Hp detection: 14C urea breathing test, DPM value >= 100 indicates the presence of Hp infection and requires anti Hp treatment. 4.Life history: No smoking or alcohol abuse history, normal lifestyle and dietary habits during treatment 5.Voluntarily participate in the study and sign an informed consent form 6.Drug history: Within 2 months prior to the first specimen collection, no antibiotics, probiotics, or various drugs that inhibit gastric acid secretion were taken; No history of eradicating Hp treatment
Exclusion criteria
Exclusion criteria: 1.Previous history of Hp eradication 2.Previous history of gastric surgery 3.Have used antibiotics, anti gastric acid secretion drugs, bismuth supplements, probiotics or been allergic to any of the above drugs within 8 weeks 4.Subjects currently participating in clinical studies of other drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 14C UBT DPM value;SCL-90 psychological health score;Gastrointestinal symptoms score; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum inflammatory factors; gut microbiota; | — |
Countries
China
Contacts
Public ContactShi Mai
Jilin Medical University,Affililated Hospital of Jilin Medical University
Outcome results
None listed