Hymerectomy with hemodynamic fluctuations after intraoperative injection of posterior pituitary lobes
Conditions
Interventions
Group A:1 mg/kg lidocaine is injected during anesthesia induction
Group B:Injection of 0.05 ml/kg normal saline (equal milliliter amount of lidocaine) at anesthesia induction
Sponsors
The First Affiliated Hospital,Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who underwent elective laparoscopic myomectomy in our hospital; 2. ASA grading I-II; 3. Age 18-65 years old; 4. Voluntarily accept patient-controlled intravenous analgesia pump analgesia; 5. Voluntarily participate in this study, and communicate without barriers;
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to the use of lidocaine; 2. Those with a history of drug abuse or alcoholism; 3. Those who have participated in clinical trials related to lidocaine in the past; 4. Patients with ASA grade greater than or equal to grade III, abnormal preoperative vital organs or endocrine system, immune function, liver and kidney insufficiency, and coagulation dysfunction; 5. Patients with inflammation and fever and body infection before surgery; 6. Patients with preoperative mental problems (chronic depression or severe bipolar disorder); 7. Patients who are unable to communicate effectively with the investigator or refuse to participate in the experiment; 8. Patients with intraoperative blood loss exceeding 800ml or shock requiring a large amount of blood transfusion; 9. Patients with serious complications within 6 hours after surgery, such as delayed bleeding, multi-organ insufficiency or critically ill transfer to intensive care unit; 10. BMI >=35kg/?; 11. other factors that prevent patients from cooperating with the study protocol;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The degree of blood pressure fluctuation after posterior pituitary injection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immediate resting pain after extubation;Dose of vasoactive drug immediately from the start of surgery to extubation;Propofol dosage;The amount of analgesic medication used immediately from the start of surgery to extubation;Incidence of sore throat within 30 minutes after extubation;Incidence of cough immediately after extubation;off-bed time;The time to persistently elevate mean arterial pressure after intraoperative injection of posterior pituitary phyllin; | — |
Countries
China
Contacts
Public ContactDuan Xiaoyun
The First Affiliated Hospital,Sun Yat-sen University
Outcome results
None listed