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Elevated serum tryptase levels and altered heart rate variability in patients with heart failure

Elevated serum tryptase levels and altered heart rate variability in patients with heart failure

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500101765
Enrollment
Unknown
Registered
2025-04-29
Start date
2024-11-22
Completion date
Unknown
Last updated
2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure

Interventions

Heart failure group:NA

Sponsors

Renmin Hospital of Wuhan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Participants were aged between 40 and 90 years16. 2. 24-hour ambulatory electrocardiogram (Holter) monitoring was performed upon admission14. 3. Comprehensive laboratory tests were conducted, including cardiac ultrasonography, pro-B-type natriuretic peptide (proBNP), complete blood count, hepatic and renal function panels, blood glucose, electrolyte levels, and lipid profile

Exclusion criteria

Exclusion criteria: 1. Patients with non-sinus rhythm (e.g., atrial flutter, atrial fibrillation, severe atrioventricular block, or pacemaker implantation); 2. Presence of other diseases affecting autonomic nervous function, such as hyperthyroidism, psychiatric disorders, or neurological disorders; 3. Comorbid severe valvular heart disease; 4. Severe infection; 5. Severe renal insufficiency (eGFR <30 mL/min/1.73m²); 6. Rheumatic and autoimmune diseases; 7. Life-limiting diseases other than coronary artery disease; 8. Psychologically or legally incapacitated; 9. History of malignant tumors; 10. Inability to cooperate with the study.

Design outcomes

Primary

MeasureTime frame
Trypase;

Secondary

MeasureTime frame
Heart Rate Variability;

Countries

China

Contacts

Public ContactLilei Yu

Renmin Hospital of Wuhan University

lileiyu@whu.edu.cn+86 158 2753 7180

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026