Heatstroke
Conditions
Interventions
Research group:The mode of blood purification treatment was HP (cytokine adsorption column CA330) CVVHDF (ULtrafluxAV600S) tandem
Control group:Receiving blood purification treatment mode is CVVHDF (ULtrafluxAV600S)
Sponsors
The First Affiliated Hospital of University of South China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-80 years old; 2. Meet the diagnostic criteria for heat stroke and initiate CBP treatment. Diagnostic criteria for heat stroke are as follows: (1) Medical history information: a. Exposure to high temperature and humidity; b. High-intensity exercise; (2) Clinical manifestations: a. Manifestations of central nervous system dysfunction (such as coma, convulsions, delirium, abnormal behavior, etc.); b. Core temperature over 40°C; c. Manifestations of functional impairment of multiple organs (>=2) (liver, kidney, rhabdomin, gastrointestinal, etc.); d. Severe coagulopathy or DIC. The diagnosis of heat stroke should be considered when either of the history information is added to the clinical presentation and cannot be explained by other causes.
Exclusion criteria
Exclusion criteria: 1) anticipation of uncontrollable severe bleeding; 2) pregnant or lactating women; 3) Those who interrupt or abandon treatment; 4) Tumor patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body temperature;Interleukin-6, IL-6;Interleukin-8, IL-8;Tumor Necrosis Factor-alpha, TNF-a; | — |
Secondary
| Measure | Time frame |
|---|---|
| White Blood Cell, WBC;Procalcitonin, PCT;C-Reactive Protein, CRP;Ferritin;Myoglobin;Blood Urea Nitrogen, BUN;Serum creatinine;Arterial blood lactate;7 - day survival rate;28 - day survival rate;Mechanical ventilation time;Length of stay in ICU;Hospitalization time;SOFA score;APACHE? score; | — |
Countries
China
Contacts
Public ContactZhou Jia
The First Affiliated Hospital of University of South China
Outcome results
None listed