Atrial fibrillation
Conditions
Interventions
Catheter ablation combined with left atrial appendage occlusion group (CA LAAC group):None
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria in the left atrial appendage occlusion group: patients with non-valvular atrial fibrillation > age 18 years old and CHA2DS2-VASC score >=2 (female>=3) with one of the following conditions: 1 not suitable for long-term standardized anticoagulation therapy; 2. Thromboembolic events still occur on the basis of long-term standardized anticoagulation therapy; 3 HAS-BLED score >=3;4 requires concomitant antiplatelet therapy; 5. Unwilling to take long-term anticoagulation therapy Inclusion criteria for the catheter ablation combined with left atrial appendage closure group: 1. Meet the above inclusion criteria for left atrial appendage closure; 2. Symptomatic nonvalvular atrial fibrillation that is ineffective or intolerant of oral anti-arrhythmic drugs;
Exclusion criteria
Exclusion criteria: 1. Left atrial inner diameter>65mm; 2. TEE found thrombus in LAA; 3. Severe mitral valve disease or medium to large pericardial effusion; 4. Patients with acute ischemic stroke with intracranial hemorrhage caused by hemorrhagic transformation or oral anticoagulation therapy, and are not suitable for restarting anticoagulation therapy after multidisciplinary evaluation; 5. Coagulation dysfunction; 6. Patients with recent active bleeding; 7. Patients with other diseases that require continued anticoagulation in addition to AF; 8. Those who need to undergo surgical thoracotomy; 9. Acute myocardial infarction, NYHA cardiac function grade IV. 10. Transthoracic echocardiography (TTE) showed left ventricular ejection fraction (LVEF) < 30%;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of DRT;Incidence of residual fistula;Incidence of thromboembolic events;Cardiovascular mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart failure readmission rate;All-cause mortality; | — |
Countries
China
Contacts
Public ContactFangmei Liu
Northern Jiangsu People's Hospital
Outcome results
None listed