Colorectal cancer
Conditions
Interventions
No opioid anesthesia group:No opioid anesthesia
Control group:Opioid anesthesia
Sponsors
The First People’s Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 30-80 years; 2.ASA class l~III; 3.Body mass index (BMI): 18 ~30 kg/m2; 4.There is no history of other malignant tumors, and there is no history of blood transfusion within two weeks before surgery; 5.Those who have not undergone chemoradiotherapy before surgery and have not used immunosuppressants; 6.Patients undergoing colorectal cancer resection under elective general anesthesia; 7.Primary school diploma or above, can complete the scale measurement; 8.Able to voluntarily cooperate with the study and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Patients with preoperative coexisting acute coronary syndrome or heart failure (EF=160mmHg and diastolic blood pressure >=105mmHg); 8.Emergency surgery; 9.History of allergy to anesthetic drugs for this treatment regimen; 10.Other conditions that in the opinion of the investigator are not suitable to participate in this trial;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Th1/Th2 ratio before anesthesia induction, postoperative day 1, day 3, day 5; | — |
Secondary
| Measure | Time frame |
|---|---|
| CD4+ T/CD8+ T ratio, number of NK cells, and NLR ratio Value before anesthesia induction, postoperative day 1, day 3, day 5;Cortisol levels before anesthesia induction and the end of surgery;Numerical Rating Scale (NRS) score on the first postoperative day;Anesthesia satisfaction on the third postoperative day (Bauer Anesthesia Satisfaction Questionnaire);Number of PCIA compressions, consumption of analgesic medications, number of analgesic remedies;postoperative nausea and vomiting and whether antiemetic drugs are used and their doses;Other postoperative complications such as respiratory depression (SpO2<94%), nerve block complications, intestinal obstruction, incision site infection, etc;Time to first postoperative exhaust;Number of days of postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactZhao Zhibin
The First People’s Hospital of Lianyungang
Outcome results
None listed