Ultrasound-guided superior laryngeal nerve block combined with general anesthesia reduces stress response to double-lumen bronchial intubation: a randomized controlled trial

An RCT study of ultrasound-guided superior laryngeal nerve block combined with general anesthesia to reduce the stress response of double-lumen bronchial intubation

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500101729

Enrollment

Unknown

Registered

2025-04-29

Start date

2025-05-01

Completion date

Unknown

Last updated

2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stress response

Interventions

Test group (Superior laryngeal nerve block group):Ultrasound-guided internal branch of superior laryngeal nerve block

Controlled group (Conventional treatment group):Routine anesthesia induction and intubation

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Unilateral thoracoscopic surgery with left double-lumen bronchial tube under general anesthesia. 2. American Society of Anesthesiologists (ASA) grade I-III. 3. aged 18-70 years old. 4. Body mass index (BMI) < 28 kg/m^2. 5. No history of cardiovascular disease. 6) no history of bronchiectasis, pulmonary carbuncle, tuberculosis, or pulmonary disease requiring pulmonary sequestration.

Exclusion criteria

Exclusion criteria: 1. Contraindications to SLNB (abnormal coagulation, infection at the puncture site or allergy to local anesthetics). 2. Predictable difficult airway (Mallampati grade III-IV, mouth opening =28kg/m^2). 3. Chronic bronchitis, asthma, or any respiratory disease that leads to reduced lung function. 4. Severe hepatic and renal dysfunction. 5. History of brain surgery or trauma. 6. History of neurological or psychiatric disorders.

Design outcomes

Primary

Measure	Time frame
Mean arterial pressure;Heart rate;Heart rate pressure product;Heart rate variability;	—

Secondary

Measure	Time frame
Serum norepinephrine levels;Serum adrenaline levels;Serum cortisol level;Postoperative sore throat;Intubation time;Complications related to tracheal intubation;Complications of postoperative cardiovascular and cerebrovascular events;Postoperative pulmonary complications;Propofol dosage from the time of double-lumen endobronchial intubation until the start of surgical skin incision;The amount of sufentanil consumed from the time of double-lumen bronchial intubation until the start of surgical skin incision;Dopamine consumption from the time of double-lumen bronchial intubation until the start of surgical skin incision;	—

Measure

Time frame

Serum norepinephrine levels;Serum adrenaline levels;Serum cortisol level;Postoperative sore throat;Intubation time;Complications related to tracheal intubation;Complications of postoperative cardiovascular and cerebrovascular events;Postoperative pulmonary complications;Propofol dosage from the time of double-lumen endobronchial intubation until the start of surgical skin incision;The amount of sufentanil consumed from the time of double-lumen bronchial intubation until the start of surgical skin incision;Dopamine consumption from the time of double-lumen bronchial intubation until the start of surgical skin incision;

—

Countries

China

Contacts

Public ContactChenfang Luo

The Third Affiliated Hospital of Sun Yat-sen University

15975604518@139.com+86 189 0300 6039

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026