Postoperative changes of lipid metabolism in patients with high body mass index
Conditions
Interventions
Fospropofol group:Application of Fospropofol Disodium for Sedation in General Anesthesia
Propofol group:Application of Propofol Disodium for Sedation in General Anesthesia
Sponsors
Chengdu Integrated TCM&Westem Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Sixty patients undergoing elective general anesthesia for non-cardiac and non-liver surgery, age range 18-80 years old, BMI: >=25 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Known drug allergy: Patients allergic to propofol or fospropofol disodium; Patients allergic to other anesthetics or adjuvant drugs used in the study. 2. Severe systemic diseases: patients with significant liver dysfunction (e. g., Child-Pugh classification class B or C); Patients with renal insufficiency (e. g., GFR8%); severe thyroid dysfunction (for example, patients with uncontrolled hyperthyroidism or hypothyroidism); Patients with diagnosed metabolic syndrome. 4. Special physiological status: pregnant or lactating women; patients with recent (within the past 6 months) history of major trauma or surgery. 5. Use of drugs that affect lipid metabolism: long-term use of steroids or other drugs that may affect lipid metabolism (eg, steroids, statins); patients using immunosuppressants (eg, cyclosporine, tacrolimus). 6. Mental illness or substance abuse: Patients with severe mental illness (e. g., major depression, schizophrenia); patients with a history of drug or alcohol abuse in the past 6 months. 7. Other: patients who are unable or unwilling to comply with the study protocol; patients who have participated in other clinical trials within the past 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver function (ALT, AST, ALP, bilirubin);Lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides);Renal function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;HbA1c;Anesthesia quality assessment; | — |
Countries
China
Contacts
Public ContactHuang Cuiyuan
Chengdu Integrated TCM&Westem Medicine Hospital
Outcome results
None listed