Postoperative Nausea and Vomiting
Conditions
Interventions
0g VitB6 Group:6 ml of normal saline intravenous infusion is given prior to anesthesia induction
0.2g VitB6 Group:0.2g/4ml vitamin B6 and 2M normal saline intravenous infusion was given before anesthesia induction
0.3g VitB6 Group:0.3g/6ml vitamin B6 intravenous infusion was administered prior to anesthesia induction
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients who are scheduled to undergo laparoscopic surgery under general anesthesia Age >= 18 years old ASA (American Society of Anesthesiologists) is graded as Class I~III Provide signed informed consent
Exclusion criteria
Exclusion criteria: Known allergy to vitamin B6 or use of vitamin B6 within a week prior to surgery Use of long-acting antiemetics and emetics within one week before surgery Long-term use of opioids or glucocorticoids Have other medical conditions that may cause nausea and/or vomiting (e.g., hepatitis, stomach ulcers) Postoperative treatment with an indwelling gastric tube is required Pregnant or lactating females Mental retardation, psychiatric illness, or severe neurological disorder Participation in other clinical studies within 3 months prior to enrollment in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting within 24 hours after surgery;Incidence of nausea;Incidence of vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting in the early postoperative period;Incidence of nausea and vomiting in late postoperative stages;The severity of the patient's nausea at 24 hours postoperatively (0 none; 1 mild; 2 medium; 3 violent);Number of vomits (1, 2, = 3);Time to first onset of nausea or vomiting (hours);Treatment of anti-nausea medications;Maximum pain score at rest/exercise within 24 hours postoperatively;Duration of stay in the PACU;Length of hospital stay;Hospitalization costs;The severity of the patient's vomiting at 24 hours postoperatively (0 none; 1 mild; 2 medium; 3 violent); | — |
Countries
China
Contacts
Public ContactLe Yuan
Department of Anesthesiology, Third Xiangya Hospital, Central South University
Outcome results
None listed