None
Conditions
Interventions
Phosphopropofol disodium group:Induction: Fospropofol disodium
Propofol group:Induction : Propofol
Sponsors
The Affiliated Tumor Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria 1. Age 18~65 years old; 2. ASA grading I-III; 3BMI18~28 kg/m^2; 4. Patients without severe tracheal stenosis and dyspnea should be diagnosed by chest X-ray or lung CT x-ray to meet the criteria for bronchoscopy; 5. Operation time<=1h; 6. Clearly understand and voluntarily participate in the study, and sign the informed consent form by himself.
Exclusion criteria
Exclusion criteria: 1. Inability to provide informed consent; 2. History of difficult airway, severe respiratory disease, respiratory dysfunction (pulse SpO2=160 mmHg or =100 mmHg), uncontrolled diabetes mellitus (HbA1c>9%), coronary heart disease; Patients with severe cardiovascular and cerebrovascular diseases, liver and kidney insufficiency (Child-Pugh score >7, eGFR<30 ml/min/1.73 m²), myasthenia gravis, schizophrenia, severe depressive state and other diseases; 4. Allergic disease or allergy to the study drug; 5. Family history of malignant hyperthermia; 6. Participated in other drug clinical trials as a subject in the past 3 months; 7. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative circulatory status (mean arterial pressure and heart rate); | — |
Secondary
| Measure | Time frame |
|---|---|
| Primary efficacy endpoint: Proportion of subjects with MOAA/S =1 at 5 minutes after first dose administration;Induction time for groups P and F;Total intraoperative consumption of propofol and remifentanil in the two patient groups;Incidence of postoperative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactHu MengRong
The Affiliated Tumor Hospital of Guizhou Medical University
Outcome results
None listed