Endometrial hyperplasia without atypia?Endometrial hyperplasia with atypia?Endometrial cancer
Conditions
Interventions
Index test:Methylation Testing ?Liquid-Based Cytology?minimal tissue specimens
Sponsors
Second Xiangya Hospital of CSU
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients presenting with irregular vaginal bleeding; 2.Individuals with increased risk factors (meeting >=1 of the following criteria AND concurrent endometrial thickening): (1) Obesity (body mass index, BMI >=30 kg/m²); (2) Polycystic ovary syndrome (PCOS); (3) History of unopposed estrogen therapy (without progesterone antagonism); (4) Late menopause (>55 years old); (5) Nulliparity or primary infertility; (6) Long-term tamoxifen therapy (especially in patients >50 years old or postmenopausal); (7) Age >=45 years with concurrent diabetes mellitus. Endometrial thickening criteria: Premenopausal women: endometrial thickness >=11 mm; Postmenopausal women: endometrial thickness >=5 mm; 3.High-risk populations: Lynch syndrome carriers and their first-degree relatives, screened annually after 30–35 years of age (or 5–10 years before the earliest cancer diagnosis age in affected family members).
Exclusion criteria
Exclusion criteria: 1.Patients during menstruation, pregnancy, or lactation; 2.Patients who have undergone hormonal therapy within the past 3 months; 3.Patients with concurrent malignancies or autoimmune diseases; 4.Patients with psychiatric disorders or inability to comply with the study protocol; 5.Patients with an intrauterine device (IUD) in situ; 6.Patients with a history of recent intrauterine procedures (within 1 month), including: Uterine curettage, Endometrial biopsy, IUD insertion/removal, Other endometrial trauma; 7.Incomplete medical records or unavailable pathological imaging data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathology results of minimal tissue specimens; | — |
Secondary
| Measure | Time frame |
|---|---|
| Methylation Testing; | — |
Countries
China
Contacts
Public ContactFu Chun
The Second Xiangya Hospital of Central South University
Outcome results
None listed