Colorectal cancer
Conditions
Interventions
Propofol group:Anesthesia Maintenance: In the Propofol group, anesthesia was maintained with Propofol 4–8 mg/kg/h and Remifentanil 0.05–0.20 µg/kg/min. The dose of Propofol was adjusted to maintain th
Remimazolam group:Anesthesia Induction: In the Remimazolam group, general anesthesia was induced with Remimazolam 0.2 mg/kg, intravenous Sufentanil 0.5 µg/kg, and Cisatracurium 0.15 mg/kg.
Anesthesia
Sponsors
The First Affiliated Hospital of Nanjing Medical University, Nanjing
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Primary colorectal cancer; 2. Planned laparoscopic radical colorectal cancer resection; 3. Age 60-90 years old.
Exclusion criteria
Exclusion criteria: 1. Patients who have recently taken psychotropic drugs and have mental disorders; 2. Patients who have had postoperative delirium; 3. Patients who are allergic to propofol or benzodiazepines; 4. Patients with severe respiratory, cardiac, liver and kidney insufficiency before surgery; 5. Previous diagnosis of Alzheimer's disease or dementia, and impaired cognitive function indicated by short-term well-being tests. 1. Patients who have recently taken psychotropic drugs and have mental disorders; 2. Patients who have had postoperative delirium; 3. Patients who are allergic to propofol or benzodiazepines; 4. Patients with severe respiratory, cardiac, liver and kidney insufficiency before surgery; 5. Previous diagnosis of Alzheimer's disease or dementia, and impaired cognitive function indicated by short-term well-being tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery time (time from the end of surgery to tracheal extubation);Length of stay; | — |
Countries
China
Contacts
Public ContactRao Zhuqing
The First Affiliated Hospital of Nanjing Medical University, Nanjing
Outcome results
None listed