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Comparison of Analgesic Efficacy between Single-injection Paravertebral Block With Liposomal Bupivacaine and Continuous Paravertebral Block with Ropivacaine for Postoperative Pain in Thoracoscopic Surgery: A Randomized Controlled Trial

Comparison of Analgesic Efficacy between Single-injection Paravertebral Block With Liposomal Bupivacaine and Continuous Paravertebral Block with Ropivacaine for Postoperative Pain in Thoracoscopic Surgery: A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500101697
Enrollment
Unknown
Registered
2025-04-28
Start date
2025-04-28
Completion date
Unknown
Last updated
2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Interventions

1:Liposomal Bupivacaine 266mg/20ml for Single-Injection Paravertebral Nerve Block
2:Ropivacaine 110mg/350ml for Continuous Paravertebral Block

Sponsors

Huadong Hospital of Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for elective thoracoscopic lobectomy at our hospital; 2. Age >= 18 years; 3. American Society of Anesthesiologists (ASA) Physical Status Classification I-III.

Exclusion criteria

Exclusion criteria: 1. BMI <30 kg/m^2; 2. Severe cardiopulmonary dysfunction; 3. Severe allergies (e.g., to soy, milk); 4. History of chronic pain (e.g., due to bone metastasis); 5. Infection at the puncture site; 6. Coagulation disorders; 7. Spinal deformities; 8. Psychiatric or cognitive disorders.

Design outcomes

Primary

MeasureTime frame
VAS Score at 48 Hours Postoperation;—

Secondary

MeasureTime frame
VAS Score at 24 Hours Postoperation;Number of Postoperative Rescue Analgesia Administrations;Postoperative C-reactive Protein (CRP);Postoperative Pulmonary Complications (PPCs) Grading Score;Postoperative Nausea and Vomiting (PONV) Score;Patient Postoperative Satisfaction;—

Countries

China

Contacts

Public ContactGu Weidong

Huadong Hospital of Fudan University

mcwgwd@163.com+86 138 1893 7242

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026