Renal Ischemia Reperfusion Injury
Conditions
Interventions
Control:No Intervention.
Glimepiride treatment group:Take glimepiride 2 mg orally every day starting from the day of the surgery for one week.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Recipients of kidney transplants using deceased donor kidneys; 2. Adult recipients aged 18 to 65 years, regardless of gender; 3. Recipients undergoing their first kidney transplant; 4. Voluntarily signing a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Multi-organ transplantation; 2. Recipients with signs of active infection; 3. Preoperative assessment showing significant size or function discrepancy in both kidneys of the donor (>5%); 4. Recipients allergic to glimepiride, other sulfonylureas, other sulfonamides, or any components of the product; 5. Recipients with abnormal blood glucose levels or those who have been on sulfonylureas like glimepiride for a long time; 6. Recipients who are pregnant or breastfeeding, or women unwilling to use appropriate contraception during the study; 7. Recipients currently infected with HIV, HBV, HCV, or those with severe liver damage; 8. Patients with severe gastrointestinal diseases or active peptic ulcer disease; 9. Patients with any mental illness; 10. Patients with severe heart disease and abnormal cardiac function; 11. Any transplantation with ABO blood type or HLA antibody incompatibility; 12. Recipients participating in other experimental drug trials; 13. Recipients unable to comply with study requirements; 14. Other recipients deemed unsuitable for enrollment at the discretion of the supervising physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Creatinine;Blood Urea Nitrogen;Delayed Graft Function;Donor derived cell free DNA; | — |
Secondary
| Measure | Time frame |
|---|---|
| TNF-a;IL-1ß;Interleukin-6;IL-10;IL-18;Proteinuria;Urine volume;Renal biopsy;eGFR;Acute rejection;Graft Survival;Survival rate of kidney transplant recipients; | — |
Countries
China
Contacts
Public ContactZhongli Huang
West China Hospital, Sichuan University
Outcome results
None listed