None
Conditions
Interventions
Liposomal bupivacaine ropivacaine mixed group:Liposomal bupivacaine 20 ml mixed with 5 ml of 0.375% ropivacaine hydrochloride injection was used for thoracic paravertebral nerve block.
Ropivacaine group:The ropivacaine group was medicated with 0.375% ropivacaine hydrochloride 25 ml for thoracic paravertebral nerve blocks.
Liposomal bupivacaine group:In the liposomal bupivacaine group, liposomal bupivacaine 266 mg 20 ml mixed with 5 ml of saline was used for thoracic paravertebral nerve block.
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-65, ASA I-III; 2.Patient with proposed single-port thoracoscopy-assisted partial resection/ segment resection/lobectomy under general anesthesia; 3.Consent for regional nerve block and postoperative intravenous self-controlled analgesia.
Exclusion criteria
Exclusion criteria: 1. Converted to open thoracic surgery; 2. Contraindicated to deep nerve block; 3. Preoperative severe hepatic or renal insufficiency; 4. Chronic opioid dependence and chronic users of various types of pain medication; 5. Alcohol and/or drug abuse; 6. Known hypersensitivity to local anesthetics; 7. Hard to communicate due to severe dementia, language impairment, or end-stage disease; 8. Recent antipsychiatric medication use; 9. Expected to be admiitted to ICU; 10. With the situations which preclude the participation in the opinion of the investigator or the attending physician;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area Under the Curve (AUC) of the Numeric Rating Scale (NRS) Pain Intensity Score at 0-72 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative 2-72h pain intensity ratings and indicators of opioid consumption;Block quality was evaluated: dermatomal block range, time to peak block, total duration of nerve block manipulation, and nerve block-related adverse events;;Bupivacaine concentration in blood;Opioid use in the 72h postoperative period; | — |
Countries
China
Contacts
Public ContactSong Linlin
Peking University First Hospital
Outcome results
None listed