advanced solid tumor
Conditions
Interventions
A(SBRT):None
B(SBRT-SIB):None
Sponsors
Hainan Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1, >=18 years of age; 2. malignant tumors confirmed by cells or pathology; 3. Primary, recurrent or metastatic tumors, >= 5 cm in diameter, or involving important organs, in patients who cannot undergo surgery, failed first-line treatment, or refused chemotherapy; 4. KPS >=60 points; 5. Survival is expected to be >=3 months; 6. No serious comorbidities (bone marrow, liver and kidney function, coagulation function, heart function) (WBC>=3.0×10^9/L, ANC>=1.5 ×10^9/L, PLT>=90×10^9/L, HGB>=8g/dL; TBIL4 weeks; 8. sign written informed consent; 9. agree to collect biological specimens of tissue or blood) for standby;
Exclusion criteria
Exclusion criteria: 1, received radiotherapy at the same site within 3 months; 2. in pregnancy or lactation; 3. Diffuse metastases of the central nervous system (brain, meninges, spinal cord); 4. severe comorbidities (severe infection, bone marrow depression, cardio-cerebrovascular disease, persistent or intractable epilepsy; severe cardiac insufficiency, coagulation disorder, active hemorrhage, electrolyte disturbances); 5. KPS <60 points; 6. Any arterial thrombosis, embolism, or ischemia that occurred within; 6 months before enrollment, such as myocardial infarction, unstable angina, cerebrovascular accident, or transient ischemic attack; 7. previous history of mental illness, alcohol abuse, drug use, or substance abuse;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| objective respone rate (ORR);local control rate (LCR); | — |
Secondary
| Measure | Time frame |
|---|---|
| physical parameters of radiotherapy planning;progress-free survival (PFS);overall survival (OS);Correlation between lymphocyte subsets response and treatment;toxico-complications; | — |
Countries
China
Contacts
Public ContactLuo Yunxiu
Hainan Cancer Hospital
Outcome results
None listed