Hysteroscopic surgery
Conditions
Interventions
0.015mg/kg group:0.015mg/kg Oliceridine
0.025mg/kg group:0.025mg/kg Oliceridine
0.02mg/kg group:0.02mg/kg Oliceridine
0.01mg/kg group:0.01mg/kg Oliceridine
0.03mg/kg group:0.03mg/kg Oliceridine
Sponsors
Zhejiang Xiaoshan Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for hysteroscopy requiring intravenous anesthesia; 2. American Society of Anesthesiologists (ASA) physical status I or II; 3. Aged 18 to 55 years; 4. Body mass index (BMI) between 18 and 25 kg/m^2;
Exclusion criteria
Exclusion criteria: 1. History of cardiopulmonary diseases,including ECG abnormalities (QTc interval of >470 milliseconds ); 2. Women who were pregnant or breastfeeding; 3. Hepatic and renal dysfunction; 4. Obstructive sleep apnea-hypopnea syndrome(OSAHS); 5. Use of agents that could affect analgesic response (central a-adrenergic agents, antiepileptics, neuroleptics, antidepressants, antipsychotics); 6. History of narcotics such as opioid and propofol hypersensitivity; 7. At risk of aspiration; 8. Difficulty with cervical dilatation, defined as dilatation lasting > 5 minutes;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate in each dose group (0.01,0.015,0.02,0.025, or 0.03 mg·kg–1 group); | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to anesthesia emergence;Intraoperative vital signs;Surgery duration;Visual analogue scale (Vas) pain score;Adverse reactions;Propofol requirements; | — |
Countries
China
Contacts
Public ContactSong Congzhong
Zhejiang Xiaoshan Hospital
Outcome results
None listed