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Application of Liposomal Bupivacaine Combined with Bupivacaine Hydrochloride in Brachial Plexus Block for Open Reduction and Internal Fixation of Proximal Humerus Fractures

Application of Liposomal Bupivacaine Combined with Bupivacaine Hydrochloride in Brachial Plexus Block for Open Reduction and Internal Fixation of Proximal Humerus Fractures

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500101662
Enrollment
Unknown
Registered
2025-04-28
Start date
2025-07-07
Completion date
Unknown
Last updated
2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Proximal Humerus Fracture

Interventions

Experimental Group:Liposomal bupivacaine in combination with bupivacaine

Sponsors

Nanjing Pukou District Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age 18 to 75 years old; 2. American Society of Anesthesiologists (ASA) grade I-III; 3. The first open reduction and internal fixation of the proximal humerus fracture; 4. No contraindications to postoperative rehabilitation training.

Exclusion criteria

Exclusion criteria: 1. Patients with a known history of liposomal bupivacaine and bupivacaine allergy; 2. Patients admitted to ICU for monitoring and treatment after surgery; Patients who refuse to undergo rehabilitation training after surgery; 3. Patients with previous long-term oral opioid analgesics, patients who have participated in other drugs or clinical trials.

Design outcomes

Primary

MeasureTime frame
Postoperative pain scores at different time points in resting state;Pain scores during rehabilitation exercises at different postoperative time points;Postoperative intravenous analgesia application;Progress of postoperative motor function rehabilitation;

Secondary

MeasureTime frame
Complication rate of peripheral nerve blocks;

Countries

China

Contacts

Public ContactPengpeng Zhang

Nanjing Pukou District Hospital of Traditional Chinese Medicine

zppdoc@foxmail.com+86 182 5208 5123

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026