Therapeutic Efficacy of Oxycodone/Acetaminophen Combined with Bisphosphonates in Bone Metastasis-Induced Cancer Pain and Its Modulation of Pain-Related Mediators

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500101653

Enrollment

Unknown

Registered

2025-04-28

Start date

2025-05-12

Completion date

Unknown

Last updated

2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Metastasis-Induced Cancer Pain

Interventions

Control group: Oxycodone hydrochloride prolonged-release tablets group:None

Intervention group (oxycodone/acetaminophen):None

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >=18 years with histologically confirmed malignancy; 2.Stage III/IV advanced cancer; 3.Bone metastases verified by imaging (ECT/CT/MRI); 4.Capacity for oral drug intake; 5.Intact cognitive and communication function.

Exclusion criteria

Exclusion criteria: 1.Recent anticancer therapy (chemotherapy/radiotherapy/endocrine therapy) within 30 days pre-enrollment; 2.Respiratory depression, hypercapnia, or bowel obstruction; 3.Hepatic/renal insufficiency, chronic viral hepatitis, or peptic ulcer history; 4.Alcohol abuse or opioid misuse 5.Contraindications to trial drugs.

Design outcomes

Primary

Measure	Time frame
Pain relief;	—

Secondary

Measure	Time frame
Breakthrough Pain Characteristics;Pain-Related Mediators;Inflammatory Markers;	—

Countries

China

Contacts

Public ContactWeifeng Jiang

Quzhou People Hospital

853800312@qq.com+86 15157012931

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026