Knee osteoarthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) According to the American College of Rheumatology (ACR) clinical classification criteria of knee osteoarthritis. (2) Aged 38-75 years; (3) Knee osteoarthritis confirmed by imaging, Kellgren-Lawrence grade I-III; (4) According to visual analogue scale (VAS) score >= 3; (5) Able to listen, speak, read and understand Chinese, able to use mobile devices, able to understand the requirements of the trial, willing to cooperate with the investigators in the trial, and willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1: Pregnant or nursing women 2: Patients suffering from systemic osteoarthritis, those who have previously undergone surgery on a lower extremity, patients with septic arthritis, and patients with traumatic joint events that are to be treated. 3: The following diagnoses have been made: rheumatoid arthritis, gout, and severe osteoporosis. 4: The existence of chronic pain as a consequence of another pain disorder. 5: The subject has a medical history that includes severe renal, hepatic, cardiac, gastrointestinal and haematological disease. 6: Neurological or psychiatric disorders diagnosed alongside malignancy; 7: The subject has been diagnosed with an atopic or allergic disease. 8: A history of epilepsy or the use of antiepileptic medication is a contraindication. 9: The ingestion of pharmaceuticals that modify the excitability of the cerebral cortex (for instance, sedative-hypnotic drugs or antidepressants) will also be excluded. 10: The patients have used non-steroidal anti-inflammatory drugs in the past 2 weeks 11: The Mini-Mental State Examination (MMSE) scale score is less than 24;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale(VAS);Functional Near-infrared Spectroscopy brain activity;Balance Function;Short Form 12 Health Survey(SF-12); | — |
Countries
China
Contacts
Zhujiang Hospital, Southern Medical University