Septicemia diaphragmatic dysfunction
Conditions
Interventions
Experimental group :The patients were treated with external diaphragm pacing on the basis of the treatment regimen of the control group.
control group:Patients with sepsis are given basic drug therapy according to current guidelines.
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for sepsis (refer to the 2021 diagnostic criteria for sepsis) without respiratory failure (oxygenation index >=300); 2. Age > 18 years to be eligible to be a study subject; 3. No contraindications to electrical stimulation; 4. No mechanical ventilation prior to inclusion in the study.
Exclusion criteria
Exclusion criteria: 1. Chest drainage, coma can not cooperate; 2. Pregnancy, diaphragmatic malformation; 3. Abdominal surgery in the past month; 4. Use of sedatives, neuromuscular blocking agents; 5. Pneumothorax, non-align fracture of ribs; 6. Active tuberculosis; 7. Those who have metal inside, fixed or installed pacemaker in the chest; 8. Non-removable wrap on the right chest wall.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Diaphragm function (end-inspiratory thickness, range of motion, thickening rate, end-expiratory thickness);Laboratory indicators (inflammatory markers, BNP, TNI, liver and kidney function, electrolytes, PCO2);8-week death/readmission rate; | — |
Countries
China
Contacts
Public ContactWang Mingjian
Shanghai Tongji Hospital
Outcome results
None listed