Obstetric antiphospholipid syndrome
Conditions
Interventions
Healthy control group:None
Sponsors
The Second Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1.Met the diagnostic criteria for obstetric antiphospholipid syndrome (OAPS) established by the Chinese Society of Perinatal Medicine; 2. Received standardized OAPS treatment at our hospital before and during pregnancy; 3.Complete medical records with telephone follow-up documenting maternal and neonatal outcomes for all cases.
Exclusion criteria
Exclusion criteria: 1.Secondary antibody positivity caused by systemic lupus erythematosus, Rheumatoid arthritis, rheumatoid arthritis, etc., leads to secondary elevation of antiphospholipid antibodies (aPL). Patients with other autoimmune diseases were also included in the statistical analysis; 2.Adverse fetal outcomes are associated with fetal structural abnormalities, genetic factors, placental factors, and other elements; 3.Adverse pregnancy outcomes are related to maternal comorbidities such as infections, inflammatory conditions, malignancies, toxic exposures, and endocrine disorders; 4. Cases with incomplete data or loss to follow-up were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antiphospholipid Antibodies (aPL);Blood biomarkers (blood glucose, placental growth factor (PlGF), folic acid, vitamin D, hCG, etc.);Placental perfusion test(VI, FI, VFI, UMA, HOLO UMA, etc.);Metabolomics (serum, urine, and placental tissue);Obstetric Multimodal Ultrasound Imaging(Placental thickness during pregnancy, three-dimensional placental ultrasound with VOCAL, amniotic sac volume, umbilical artery (UA), uterine artery (UtA), ductus venosus (DV), etc.);General Clinical Data (Blood Pressure, BMI, etc.);Fetal multimodal ultrasound imaging(etal craniocerebral, renal perfusion, cardiac function, crown-rump length (CRL), etc.);Gut microbiome detection; | — |
Countries
China
Contacts
Public ContactHong-Xia Yu
The Second Affiliated Hospital of Zhengzhou University
Outcome results
None listed