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A study for predicting responce and prognosis in primary hepatocellular carcinoma treated with immunotherapy plus targeted therapy

Radiomics model based on deep learning for predicting responce and prognosis in primary hepatocellular carcinoma treated with immune checkpoint inhibitors plus anti-angiogenic targeted therapy: a retrospective study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500101604
Enrollment
Unknown
Registered
2025-04-27
Start date
2025-04-28
Completion date
Unknown
Last updated
2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

unresectable primary hepatocellular carcinoma

Interventions

Training cohort and Validation cohort:None

Sponsors

Xiangyang Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.clinical or histopathological diagnosis of HCC; 2.patients received immune checkpoint inhibitors plus anti-angiogenic targeted therapy with or without interventional therapy as first line treatment for initial diagnosis; 3.patients performed liver computed tomography plain scan within one month prior to initial therapy and at least one measurable target lesion was available for the tumor response evaluation; 4.The follow-up of the retrospective study is not interrupted and clinical datas are complete.

Exclusion criteria

Exclusion criteria: 1.histopathological diagnosis was other pathological types,such as cholangiocarcinoma,neuroendocrine carcinoma and so on; 2.a combination of other malignant cancers; 3.patients received other therapies for liver tumors except immune checkpoint inhibitors,anti-angiogenic targeted therapy and interventional therapy,such as radiotherapy and surgical resection; 4.lack of clinical datas.

Design outcomes

Primary

MeasureTime frame
Therapeutic evaluation;

Secondary

MeasureTime frame
Progression-Free Survival(PFS);Overall Survival(OS);

Countries

China

Contacts

Public ContactLi Yong

Xiangyang Central Hospital

yongnx520@126.com+86 710 2812939

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026