Obesity
Conditions
Interventions
Opioid group:Sufentanil 2.5 ug/kg (LBW), dexmedetomidine 1 µg/kg (LBW), Ondansetron 16 mg-- 100 ml
Esketamine group:Esketamine 1 mg/kg (TBW), Sufentanil 1 µg/kg (LBW), Dexmedetomidine 1 µg/kg (LBW), Ondansetron 16 mg-- 100 ml
Sponsors
Taizhou People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old. 2. American Society of Anesthesiologists (ASA) Classifications II-III. 3. Body mass index (BMI) >= 30 kg/m^2. 4. Patients undergoing elective laparoscopic sleeve gastrectomy and choosing to apply an analgesic pump after surgery.
Exclusion criteria
Exclusion criteria: 1. Allergy to any of the medications used in the study. 2. Known glaucoma, hyperthyroidism or pheochromocytoma, grade III hypertension (very high risk), severe cardiac arrhythmia, severe cardiovascular and cerebrovascular disease, or hemodynamic instability. 3. Severe liver and kidney insufficiency. 4. Preoperative use of sedatives or analgesics (any sedative-hypnotic drugs such as benzodiazepines and non-benzodiazepine receptor agonists or opioids such as morphine, fentanyl, and oxycodone). 5. Refusal to provide informed consent or inability to collaborate with the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative analgesia; | — |
Countries
China
Contacts
Public ContactLin Jiang
Taizhou People's Hospital
Outcome results
None listed