Mild to moderately active Crohn's disease in adults
Conditions
Interventions
Control group:None
CDED+PEN group:None
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients with mildly to moderately active CD (CDAI score of 150-450 and within 4 weeks* endoscopic manifestations or biochemical indicators suggestive of active disease (hsCRP>5mg/L or ESR>20mm/hour or FCalp>50 µg/g))*: For patients with recent changes in medication, endoscopic/biochemical results should be collected after 4 weeks of medication stabilization. 2. Age 18-70 years old; 3.CD Stable dose of related medications (5-ASA, biologics, immunosuppressants, etc.), no dose adjustment within 4 weeks prior to enrollment; 4. Understand and be willing to cooperate with the study and follow-up, and give oral or written informed consent. *: For patients with recent medication changes, endoscopic/biochemical results should be collected after 4 weeks of medication stabilization.
Exclusion criteria
Exclusion criteria: 1. Be pregnant or lactating; 2. Those with current disease in B2 (presence of fixed non-inflammatory stricture 1 or small bowel obstruction) or type B3; 3. Those who are intolerant to CDED essential foods or PEN; 4. Patients with severe vomiting, intractable diarrhea or short bowel syndrome; 5. Patients with current intestinal infection (positive stool culture or positive test for parasite or Clostridium difficile, or positive blood CMV-DNA); 6. Patients with only upper gastrointestinal tract involvement; 7. Patients with diabetes mellitus, renal insufficiency or hepatic insufficiency. 1: Only patients with ileocecal stenosis could be included in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Crohn's disease activity index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Simple endoscopic score for Crohn's disease; | — |
Countries
China
Contacts
Public ContactHong Yang
Peking Union Medical College Hospital
Outcome results
None listed