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NEPA and dexamethasone for preventing of chemotherapy induced nausea and vomiting in colorectal cancer patients with high risk factors receiving moderately emetogenic chemotherapy, a single-center experience

NEPA and dexamethasone for preventing of chemotherapy induced nausea and vomiting in colorectal cancer patients with high risk factors receiving moderately emetogenic chemotherapy, a single-center experience

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500101568
Enrollment
Unknown
Registered
2025-04-27
Start date
2025-04-27
Completion date
Unknown
Last updated
2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer

Interventions

Observation group:None

Sponsors

Peking University Shenzhen Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1) Histopathological diagnosis of CRC; 2) Age 18 to 75; 3) The score of Eastern Cooperative Oncology Group Performance Status(ECOG PS) was 0-1; 4) Patients with no severe underlying hematological, hepatic, or renal diseases before the diagnosis of CRC cancer; 5) The first-line therapy regimen of all the patients was based on oxaliplatin or irinotecan;6) The CRC patients should be with high risk factors such as female, age under 50, non-drinkers or drinking a few, history of pregnant-related vomiting, history of motion sickness, history of anxiety, history of nausea and vomiting caused by chemotherapy medicine previously, expectations of nausea and vomiting, patients treated with medicine(such as opioid analgesics).

Exclusion criteria

Exclusion criteria: 1)Inability in oral medicine; 2) Allergy to NEPA or its components.

Design outcomes

Primary

MeasureTime frame
Complete remission;

Secondary

MeasureTime frame
Complete control, CC);Complete protection, CP);

Countries

China

Contacts

Public ContactTong Gangling

Peking University Shenzhen Hospital

tgl221747@sohu.com+86 151 0755 9056

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026