Autism Spectrum Disorder
Conditions
Interventions
ASD-Repetitive Transcranial Magnetic Stimulation Group ( active stimulation group):Continuous theta burst stimulation ( cTBS)
ASD-Repetitive Transcranial Magnetic Stimulation Group ( sham stimulation group):Sham Stimulation
ASD-Modulated Gut Microbiota Group ( experimental group):Probiotics or Synbiotics
ASD-Modulated Gut Microbiota Group ( placebo group):Placebo
ASD-Blank control group:None
Typical developmental control group:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
3 Years to 17 Years
Inclusion criteria
Inclusion criteria: (1) Autism group: aged 3-17 years; Met the DSM-5 criteria for autism spectrum disorder; Wechsler Intelligence Test IQ score greater than 70 points; Right handed; No antipsychotic medication; In addition, patients with gastrointestinal symptoms, antibiotics, probiotics or prebiotics, antacids and other drugs affecting gastrointestinal flora within 3 months before enrollment, DHA, vitamins and other nutritional drugs were not required. (2) Healthy control group: aged 3-17 years; Did not meet the DSM-5 criteria for autism spectrum disorder; Wechsler Intelligence Test IQ score greater than 70 points; Right handed; He was not taking antipsychotic medications.
Exclusion criteria
Exclusion criteria: 1. History of other mental disorders, such as attention deficit hyperactivity disorder, schizophrenia, etc. 2. History of other definite organic brain diseases, such as craniocerebral trauma, epilepsy, infectious diseases, and immune system diseases; 3. Have definite inherited metabolic diseases, such as Down syndrome, fragile x syndrome, Angel syndrome, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Autism Behavior Checklist (ABC);Social Responsiveness Scale(SRS);Repetitive Behavior Scale-Revised (RBS-R);Children's Sleep Habits Questionnaire (CSHQ);Magnetic Resonance Imaging (MRI);inflammatory markers in blood; | — |
Secondary
| Measure | Time frame |
|---|---|
| Children's Eating Behaviour Questionnaire(CEBQ);Gastrointestinal Symptom Rating Scale(GSRS);Bristol Stool Scale;Cambridge Neuropsychological Test Automated Battery (Intra-Extra Dimensional Set Shift/ Rapid Visual Information Processing/ Spatial Working Memory);The Developmental Test of Visual-Motor Integration (Beery VMI);The Verbal Fluency Test (VFT);Generalized Anxiety Disorder 7 (GAD-7);Patient Health Questionnaire-9 (PHQ-9); | — |
Countries
China
Contacts
Public ContactYi Huang
West China Hospital of Sichuan University
Outcome results
None listed