Advanced or/and refractory malignant tumors
Conditions
Interventions
Accelerated hypofractionated intensity-modulated radiotherapy combined with systemic treatment group/accelerated large-fraction hypermodulated radiotherapy group:None
Sponsors
Hainan Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. >=18 years old; 2. Cellular, pathological, or malignant tumors; 3. Patients with primary, recurrent or metastatic tumors, or important organs involved, unable to undergo surgery, failure of first-line treatment or refusal of chemotherapy; 4. Previous radiotherapy at the same site>=6 months; 5. ECOG > = 60 points; 6. Estimated survival >=3 months; 7. No serious comorbidities (bone marrow, liver and kidney function, coagulation function, cardiac function) Blood routine: WBC=3.0×10^9/L, ANC>=1.5 ×10^9/L, PLT>=90×10^9/L, HGB>=8g/dL; 1 Liver function: TBIL=55%, QTcF interval 4 weeks; 9. Signed informed consent form in writing; 10. Agree to collect biological specimens, tissues or blood) for later use;
Exclusion criteria
Exclusion criteria: 1.Radiotherapy at the same site within 3 months; 2. Pregnancy or lactation; 3. Diffuse metastasis of the central nervous system (brain, meninges, spinal cord); 4. Severe comorbidities (severe infection, bone marrow suppression, cardiovascular and cerebrovascular diseases, persistent or intractable epilepsy; severe cardiac insufficiency, coagulopathy, active bleeding, electrolyte imbalances); 5. KPS<60 points; 6. Any arterial thrombosis, embolism or ischemia within 6 months before enrollment, such as myocardial infarction, unstable angina, cerebrovascular accident or transient ischemic attack, etc.; 7. Past history of mental illness, alcoholism, drug abuse or drug abuse;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR; | — |
Countries
China
Contacts
Public ContactYunxiu Luo
Hainan Cancer Hospital
Outcome results
None listed