Diminished ovarian reserve
Conditions
Interventions
Diminished ovarian reserve:Treatment with sodium phenylbutyrate
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
20 Years to 38 Years
Inclusion criteria
Inclusion criteria: 1. 20 years old= 10 b. Number of follicles in the ovarian sinus (AFC) < 5 c. AMH < 1.1 ng/ml
Exclusion criteria
Exclusion criteria: 1. Those with a history of ovarian or pelvic surgery, chemotherapy and radiotherapy in the past; 2. Patients with viral infections such as hepatitis, tumors, autoimmune diseases, endocrine diseases, metabolic diseases and acute inflammation; 3. Have a clear family history or hereditary factors of hereditary premature ovarian failure 4. Combined with hyperprolactinemia and endometriosis; 5. Pregnancy or lactation; 6. Patients who are allergic to active ingredients and excipients are prohibited; 7. Suffering from other serious heart, liver, kidney and other important organ diseases or tumors; 8. Those who have a history of taking hormone drugs in the past 2 months or those who have amenorrhea caused by drugs; 9. The investigator believes that the subject has any other factors that may affect the efficacy or safety evaluation of this study, and is not suitable to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bilateral antral follicle count;Anti Mullerian hormone; | — |
Secondary
| Measure | Time frame |
|---|---|
| Follicle stimulating hormone;Insulin resistance index for a homeostatic model; | — |
Countries
China
Contacts
Public ContactLiangshan Mu
Zhongshan Hospital, Fudan University
Outcome results
None listed