Prediabetes
Conditions
Interventions
Health control group:None
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Prediabetes Inclusion Criteria: 1. The diagnostic criteria for impaired fasting glucose (IFG) are fasting plasma glucose: 6.1mmol/L<FPG<7.0mmol/L, and plasma glucose < 7.8mmol/L 2 hours after glucose loading; 2. The diagnostic criteria for impaired glucose tolerance (IGT) are fasting plasma glucose < 7.0 mmol/L and plasma blood glucose between 7.8 mmol/L and 11.1 mmol/L 2 hours after glucose loading; 3. Or meet the conditions at the same time: between the ages of 18 and 65; Agree to participate in the study, sign the informed consent form. Inclusion criteria for healthy controls: Healthy control groups were matched 1:1 according to age, gender, and BMI.
Exclusion criteria
Exclusion criteria: 1. Patients with acute or chronic inflammatory or infectious diseases, or who receive antibiotics, probiotics, probiotics, or any other medication that may affect the intestinal microbiota in the first 3 months of inclusion; 2. Patients with persistent vomiting or suspected gastrointestinal obstruction; 3. Gastrectomy, gastric fundus folding, colostomy, and other digestive system surgeries; 4. Use of antibiotics in the past 3 months for a duration of 3 days or more; 5. Patients with moderate or severe renal impairment (blood creatinine > 2mg/dL or 177mmol/L), or abnormal liver function (ALT> twice the upper limit of average value); Moderate to severe chronic obstructive pulmonary disease; Patients with severe hypertension and cerebrovascular accidents; 6. Patients with severe cardiovascular and cerebrovascular, liver, kidney, and hematopoietic diseases; 7. Serious organic diseases, such as cancer, coronary heart disease, myocardial infarction, and stroke; 8. Suffering from infectious diseases such as tuberculosis and AIDS; 9. Excessive drinking (drinking more than 5 times a week, average 2 pairs of white wine or half a jin of yellow rice wine or more than 5 bottles of beer each time); 10. In the past three months, patients receiving medical treatment for the following diseases: cholecystitis, gastrointestinal ulcer, urinary tract infection, acute pyelonephritis, cystitis, hyperthyroidism, and other thyroid abnormalities; 11. Anemia: hemoglobin <10g/ dL; 12. Patients with physical disabilities or other reasons who are unable to take care of themselves, cannot clearly recall or answer questions, or have apparent dyskinesia; 13. Cannot guarantee sufficient time to participate in the project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal microbial composition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood biologic test results;Metabonomics; | — |
Countries
China
Contacts
Public ContactNie Shaoping/Huang Xia
The First Affiliated Hospital of Nanchang University
Outcome results
None listed