Infectious complications after pancreaticoduodenectomy
Conditions
Interventions
Experimental group:4.5g piperacillin-tazobactam intravenously within 30min prior to skin incision, re-administered intraoperatively every 240 minutes (4 hours) up to 3 times
Use of 4.5g Q8 postoperatively until 48 hours postoperative intervention
Control group:2g of ceftriaxone was given intravenously within 30min before skin incision, and 2g of QD was used postoperatively until 48 hours postoperative intervention
Sponsors
Drum Tower Hospital Affiliated to Nanjing University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.>=adult patients aged 18 years; 2. There is an indication for elective PD surgery; 3. Have one of the high-risk factors: preoperative biliary drainage, preoperative imaging or examination showing malignant tumor, preoperative history of cholangitis, BMI =25kg/m^2, preoperative history of chemotherapy, age > 65 years old; 4. The patient understands the nature of this trial and is willing; 5. Patient is able to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Antibiotic allergy; 2. Uncontrolled preoperative infection; 3. Current or recent (within the previous 1 month) systemic use of glucocorticoids; 4. Malignant tumors or secondary cancers that need to be removed in the same operation at the same time in other organs; 5. Severe liver and kidney dysfunction; 6. Pregnancy or breastfeeding; 7. Other clinical trials were enrolled in the same period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative infection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pancreatic fistula;Major complication;Postoperative hospital stay;Relaparotomy;30-d mortality;MRD Infection;Allergic reaction; | — |
Countries
China
Contacts
Public ContactXu Fu
Drum Tower Hospital Affiliated to Nanjing University School of Medicine
Outcome results
None listed