Coronary atherosclerotic heart disease
Conditions
Interventions
Oliceridine group:Ten minutes before the end of the operation, a loading dose is first administered: The experimental group is intravenously injected with 1.5 mg of oliceridine. Twenty-four-hour patie
Sufentanil group:Ten minutes before the end of the operation, a loading dose is first administered: The control group is intravenously injected with 7.5 µg of sufentanil. Twenty-four-hour patient-cont
Sponsors
Qilu Hospital of Shandong University Dezhou Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for coronary heart disease in "Internal Medicine", and undergo OPCABG treatment for three-branch coronary artery lesions; 2. Have signed an informed consent form; 3. Age > = 60 years old.
Exclusion criteria
Exclusion criteria: 1. Those with severe liver and kidney organ dysfunction; 2. Patients with autoimmune diseases, cerebrovascular diseases and malignant tumors; 3. Those who use drugs that affect mental and nervous system activity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The response rate to the experimental drug at each time point within 24 hours after the administration of the loading dose; | — |
Secondary
| Measure | Time frame |
|---|---|
| The response rate to the experimental drug at each time point within 1 hour after the administration of the loading dose;The rate of rescue analgesia within 24 hours after the administration of the loading dose; | — |
Countries
China
Contacts
Public ContactSisi Wei
Qilu Hospital of Shandong University Dezhou Hospital
Outcome results
None listed