Prostate Cancer
Conditions
Interventions
Intra-operative opioids anesthesia group:Intra-operative opioids anesthesia
Opioid-free anesthesia group:Opioid-free anesthesia
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-80 years; 2.ASA I-III classification, BMI 18-30 kg/m²; 3.Patients undergoing elective robot-assisted laparoscopic radical prostatectomy for prostate cancer; 4.Surgery and general anesthesia time >= 2 hours, postoperative hospital stay >= 3 days; 5.Patients voluntarily participated and signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of abdominal surgery; 2.Patients currently taking analgesics, sedatives, antidepressants, or hormonal medications, or those allergic to local anesthetics or other medications; 3.Patients with contraindications to epidural puncture; 4.Patients with poor general condition and a history of severe cardiovascular, respiratory, hepatic, renal, or central nervous system diseases, who may not survive for more than 3 months; 5.Patients who are unable to undergo long-term follow-up or have poor compliance; 6.Patients with poorly controlled preoperative blood pressure, with baseline preoperative blood pressure >180/100 mmHg; 7.Patients who have previously participated in the study (patients requiring re-operation during the study period).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sleep disturbance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative anxiety and depression scores;Postoperative nausea and vomiting (at PACU discharge, 24 hours postoperatively, and 48 hours postoperatively);Patient PONV (Postoperative Nausea and Vomiting) score;Postoperative pain (at PACU discharge, 24 hours postoperatively, and 48 hours postoperatively);Patient NRS (Numeric Rating Scale) score at rest and during activity (coughing);Incidence of intraoperative hypotension;PACU stay duration;perioperative complications;gastrointestinal recovery;hospital stay duration; | — |
Countries
China
Contacts
Public ContactDongtai Chen
Sun Yat-sen University Cancer Center
Outcome results
None listed