Respiratory failure
Conditions
Interventions
nCPAP group:nCPAP-assistting during intubation
Standard-care group:no oxygen or other interventions during intubation.
Sponsors
West China Second University Hospital,Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria are as follows: 1.Receiving non-invasive respiratory support; 2.Undergoing non-emergency oral-endotracheal intubation in the NICU; 3.The guardian agrees.
Exclusion criteria
Exclusion criteria: Exclusion criteria are as follows: 1.Emergency endotracheal intubation; 2.No spontaneous breathing; 3.Contraindications to non-invasive ventilation use: such as, congenital nasal deformity, congenital diaphragmatic hernia. etc; 4.Cyanotic congenital heart disease ; 5.Difficult airway assessed by the treating clinician; 6.Infant with suspected or proven respiratory infectious disease such as COVID-19 or tuberculosis, etc; or born to a mother with suspected or proven respiratory infectious disease; 7.Fatal severe deformity; 8.Guardian refuses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of first intubation attempt success; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of desaturation (SpO2 < 90%) during the first intubation attempt;Incidence of bradycardia (heart rate <100 bpm) during the first intubation attempt;Time to desaturation (SpO2 < 90%) during the first intubation attempt in seconds;Time to bradycardia (heart rate <100bpm) during the first intubation attempt in seconds ;Duration of desaturation (SpO2 < 90%) during first intubation attempt in seconds;Duration of bradycardia (heart rate <100bpm) during first intubation attempt in seconds;The magnitude of SpO2 decline during the first intubation;Duration of the first intubation success in seconds;Number of intubation attempts;Duration of all intubation attempts (successful and unsuccessful), in seconds; | — |
Countries
China
Contacts
Public ContactTao Xiong
West China Second University Hospital,Sichuan University
Outcome results
None listed