respiratory tract infection of drug resistantce bacteria colonization
Conditions
Interventions
Test group:Bacteriophage cocktail10ml,aerosol inhalation,2/day
Sponsors
First Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. 18 years old <= Age <= 100 years old 2. Patients who have been hospitalized for more than 48 hours; 3. Sputum or BALF or tracheal aspirate culture+drug sensitivity confirmed as fully resistant/pan resistant bacteria; 4. No fever, no increase in acute inflammatory markers; 5. One week repeated sampling confirmed long-term colonization of drug-resistant bacteria; 6. Informed consent and signing of consent form.
Exclusion criteria
Exclusion criteria: 1. Acute phase of lower respiratory tract infection; 2. Uncontrolled bronchial asthma; 3. Pregnant and lactating women; 4. Massive hemoptysis; 5. Cannot tolerate nebulized inhalation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sputum bacterial culture;Tracheal aspirate bacteriological culture ; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine examination; | — |
Countries
China
Contacts
Public ContactLixin Xie
First Medical Center of Chinese PLA General Hospital
Outcome results
None listed