Prediabetic patients, polycystic ovary syndrome and insulin resistance, obese or overweight individuals with one or more of the following metabolic abnormalities: TG=1.7mmol/L, or already treated
Conditions
Interventions
Nutritional Ketogenic Diet:Nutritional Ketogenic Diet
Nutritional Ketogenic Diet + Complex Peptides:Nutritional Ketogenic Diet + Complex Peptides
Limit energy balance diet:Limit energy balance diet
Sponsors
Wuxi people’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years, male or female; 2. Including pre-diabetic patients, polycystic ovary syndrome and insulin resistance, obese or overweight individuals with one or more of the following metabolic abnormalities: TG=1.7mmol/L, or already treated; HDL-c levels below 1.04mmol/L, or already receiving appropriate treatment; 420umol/L<uric acid<540umol/L; Elevated blood pressure: systolic pressure =130mmHg, or diastolic pressure =85mmHg; 3.Fatty liver, either alone or accompanied by abnormal liver enzymes.3. Women in childbearing age agree to use contraceptive measures during the test; 4. Patients can understand and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Secondary obesitysuch as hypothyroidism,Cushing's syndrome, or long-term use of drugs that lead to obesity. 2. Chronic diseases of heart, brain, liver, kidney and other organs that require a special diet or affects exercise 3. Rheumatic and immune diseases, hematological diseases or a history of malignancy. 4. Female during pregnancy or lactation. 5. Unable, unwilling or unwilling to comply with the research requirements, including lifestyle modification, return visit, and subject responsibility.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Height;weight;Waist circumference;Hip circumference;Neck circumference;Calf circumference;Thigh circumference;Blood pressure;Blood lipid;Blood sugar;OGTT;Islet function;Human body composition analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Haematological parameters;Urine analysis;Liver function;Kidney function;Anxiety scale;Depression scale;Impact of weight on quality of life questionnaire-Life version;Food intake survey; | — |
Countries
China
Contacts
Public ContactQunyan Zhou
Wuxi people’s Hospital
Outcome results
None listed