obstructive sleep apnea, allergic rhinitis
Conditions
Interventions
Control group:Conventional drug therapy
Experimental group:Subcutaneous immunotherapy
Sponsors
Shenzhen University General Hospital
Eligibility
Sex/Gender
All
Age
5 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria for obstructive sleep apnea-hypopnea syndrome as stipulated in the "Chinese Guidelines for the Diagnosis and Treatment of Obstructive Sleep Apnea in Children (2020)" or the "Multidisciplinary Guidelines for the Diagnosis and Treatment of Obstructive Sleep Apnea in Adults"; 2. Meeting the diagnostic criteria for allergic rhinitis as outlined in the "Chinese Guidelines for the Diagnosis and Treatment of Allergic Rhinitis (2022, Revised Edition)", and confirmed to be caused by Dermatophagoides farinae and/or Dermatophagoides pteronyssinus (sIgE >= 0.35 IUA/L for Dermatophagoides farinae and/or Dermatophagoides pteronyssinus); 3. Age ranging from 5 to 65 years old; 4. Having received standardized anti-allergy conventional drug treatment for at least one year before enrollment; 5. Signing the informed consent form for the clinical trial.
Exclusion criteria
Exclusion criteria: 1. Patients whose legal guardians or themselves are unable to understand or comply with the research protocol; 2. Patients with severe psychological disorders or mental illnesses; 3. Patients with severe autoimmune diseases or immunodeficiency diseases; 4. Patients with malignant tumors; 5. Pregnant women; 6. Patients with contraindications to SCIT or at high risk of severe adverse reactions. 7. Patients who have undergone or are about to undergo OSA surgery; 8. Patients who have received or are about to receive biologics (such as omalizumab, Dupilumab); 9. Patients with moderate to severe atopic dermatitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep respiratory monitoring; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale;combined symptom and medication score;Nasal resistance; | — |
Countries
China
Contacts
Public ContactLiming Li
Shenzhen University General Hospital
Outcome results
None listed