Lung cancer
Conditions
Interventions
test group:In the experimental group, oxycodone 0.1 mg/kg was given intravenously 15 minutes before the start of surgery, while 266 mg of bupivacaine liposome was diluted with saline to a total volume
control subjects:In the control group, the same mL of saline as oxycodone was given intravenously 15 minutes before the start of the operation, while 0.25% bupivacaine solution was injected into the i
Sponsors
Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective thoracoscopic lobectomy/segmental lung resection; 2. 18 years of age or older; 3. ASA classification I to III; 4. Able to understand the study protocol and provide informed consent.
Exclusion criteria
Exclusion criteria: 1. Emergency or urgent surgery, previous history of thoracic surgery, history of chronic pain, history of neurological disease; 2. severe cardiac, hepatic, or renal insufficiency; 3. allergy to anaesthetics; 4. the patient has an active infection (e.g., pneumonia) or any uncontrolled disease (e.g., diabetic ketoacidosis, gastrointestinal obstruction); 5. the patient has been enrolled in another clinical trial in the past 4 weeks; 6. Any condition that, in the judgement of the investigator, is unstable or may jeopardise the safety of the subject and compliance with the study; 7. Pregnant or breastfeeding women; 8. Hypersensitivity to the study drug or prior serious adverse reaction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score at 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15 score at 48 hours postoperatively;QoR-15 score at 72 hours postoperatively;VAS score at 6 hours postoperatively;VAS score at 24 hours postoperatively;VAS score at 48 hours postoperatively;VAS score at 72 hours postoperatively;Postoperative extubation time;Incidence of postoperative nausea and vomiting;Total postoperative opioid use;Number of postoperative remedial analgesia;Earliest time out of bed after surgery;Duration of postoperative drain retention;Length of hospitalisation; | — |
Countries
China
Contacts
Public ContactXian Ding
Affiliated Hospital of Jiangnan University
Outcome results
None listed