Severe traumatic brain injury
Conditions
Interventions
1:Controlled decompression surgery based on brain temperature
2:Controlled decompression surgery
Sponsors
The 904th Hospital of the Joint Logistics Support Force of the People's Liberation Army
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 16 - 65 years old, male or female; 2.Intracranial pressure (ICP) and brain temperature probe insertion is chosen to be intraventricular; 3.Patients with severe traumatic brain injury requiring surgical treatment (Glasgow Coma Scale [GCS] score of 3 - 8); 4.Family members who consent to ICP and brain temperature monitoring as well as subsequent multimodal monitoring; 5.The patient and their family members have been provided with an informed consent form and have signed it.
Exclusion criteria
Exclusion criteria: 1.Patients with severe systemic polytrauma, where the primary injury is not located within the brain; 2.Severe underlying medical conditions, or a history of medications such as aspirin that may alter the surgical outcome; 3.Withdrawal of treatment due to financial reasons or other non-clinical circumstances; 4.Poor compliance, inability to complete the trial according to the study protocol; 5.For any reason, the researchers deem the patient unsuitable for inclusion; 6.Failure to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day all-cause mortality;3-month Glasgow Outcome Scale-Extended (GOS-E) score; 6-month Glasgow Outcome Scale-Extended (GOS-E) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative brain swelling; Postoperative complications;Cytokines (NSE, vWF, TNF-a, and catecholamines); | — |
Countries
China
Contacts
Public ContactWang Yuhai
The 904th Hospital of the Joint Logistics Support Force of the People's Liberation Army
Outcome results
None listed