Coronary microvascular disease
Conditions
Interventions
Treatment Group:Tongxinluo capsule 2 capsules, 3 times/day
Aspirin 100mg/ day
Metoprolol sustained release tablets 23.75 ~ 95mg/ day, the dosage used to make the resting heart rate of about 60 beats/min
Lipitor 20mg/ day
Control Group:2 placebo capsules, 3 times/day
Sponsors
Shanghai Pudong New District Gongli Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 30-70 years old; 2. According to expert consensus, meet the diagnostic criteria for coronary artery microvascular disease: (1) Have typical angina symptoms; (2) Positive electrocardiogram exercise test (ST-segment ischemic downward shift >=0.1mm); (3) Coronary angiography or coronary CTA is normal or close to normal (coronary angiography only finds mild stenosis with irregular epicardial coronary wall or discontinuous lumen <20%)); or patients with obstructive coronary artery disease who have been successfully relieved by PCI and have positive early stress tests for epicardial coronary artery stenosis (typical angina pectoris and ischemic ST-T changes on ECG); or coronary angiography shows slow blood flow, and the TIMI blood flow grade < grade 3. (No spasm in subepicardial coronary arteries after intracoronary acetylcholine injection)
Exclusion criteria
Exclusion criteria: 1. Exclude acute coronary syndromes; 2. Patients who have had myocardial infarction in the past six months; 3. Patients with other heart diseases, such as valvular heart disease, congenital heart disease, cardiomyopathy, etc.; 4. Cardiac function grade III-IV; 5. Severe arrhythmia; 6. Those who cannot carry out exercise test due to joint disease, etc.; 7. Not meeting the inclusion criteria: platelets (PLT) 110umol/L; Uric acid> 0.42mol/L; Heart rate=24 kg/m^2; male body weight< 50 kg; Female weight< 40Kg; 8. Patients with resistant hypertension and severe hypotension; 9. Those who are unable to take care of themselves; 10. Pregnant and lactating women; 11. Have participated in other clinical trials in the past 1 month; 12. Those who are considered inappropriate by the investigator to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seattle Angina Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Treadmill experiment; | — |
Countries
China
Contacts
Public ContactZhang Wei
Shanghai Pudong New District Gongli Hospital
Outcome results
None listed