Upper gastrointestinal mucosal dissection
Conditions
Interventions
Propofol group (Group P) : 2mg/kg of propofol was induced by anesthesia, and 4-10mg/kg/h of propofol was maintained by anesthesia.:During endotracheal intubation and surgery, additional drugs should b
Remazolam group (R group) : Remazolam 0.4mg/kg was induced by anesthesia and remazolam 0.5-1.5mg/kg/h was maintained by anesthesia:During endotracheal intubation and surgery, additional drugs should b
Sponsors
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial Hospital)
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients of both sexes had to meet all of the following inclusion criteria: 1) age <= 65 years <= 85 years; 2) patients undergoing elective upper gastrointestinal mucosal dissection; 3)ASA grade I, II, and III; 4)18 kg/m^2 < BMI < 30kg/m^2; 5) Informed consent to participate in the study
Exclusion criteria
Exclusion criteria: Patients with any of the following could not be enrolled. 1) patients with mental disorders or nervous system diseases; 2) patients who take psychotropic drugs such as diazepam and anti-anxiety drugs, or abuse alcohol or drugs; 3) patients with language communication, vision or hearing impairment; 4) patients with airway management difficulties (modified Mahalanobis score grade IV); 5) patients whose blood pressure was not well controlled by antihypertensive drugs (sitting systolic blood pressure ?160mmHg during screening and/or diastolic blood pressure ?100mmHg during screening); 6) systolic blood pressure 2, basic SpO2<92%); 9) severe liver and renal impairment; 10) Allergic or contraindicated to benzodiazepines, propofol, and their drug components; 11) have participated in a clinical trial of remimazolam or other drugs as a subject within the past 3 months; 12) patients who were deemed by the investigators to be ineligible to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eye opening time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Upon eye opening at the end of surgery, the MOAA/S (Modified Observer's Assessment of Alertness/Sedation) score was assessed.;Timing of tracheal extubation following anesthesia cessation and sedation-agitation score during extubation;Ramsay Sedation Score at 5 minutes post-extubation ;surgical duration, and hospitalization days;Incidence rate of adverse reactions following tracheal extubation;Patient and surgeon satisfaction; | — |
Countries
China
Contacts
Public ContactZhou Suli
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial Hospital)
Outcome results
None listed