Sepsis
Conditions
Interventions
Test group:Sedation using Remazolam
Control group:Sedation using Propofol or Midazolam
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meets the Sepsis 3.0 diagnostic criteria: confirmed or suspected infection, with an increase in the SOFA score by =2 points from baseline. 2. Age >=18 years. 3. The patient or their legal guardian has signed the informed consent form related to this study.
Exclusion criteria
Exclusion criteria: 1. Pregnant women and cancer patients. 2. Acute or chronic hepatitis. 3. Liver cirrhosis. 4. Chronic renal insufficiency requiring maintenance hemodialysis. 5. Other conditions deemed unsuitable for inclusion by the physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to achieve the goal of sedation;dose of sedative required to reach target sedation;time to awakening after drug discontinuation; | — |
Secondary
| Measure | Time frame |
|---|---|
| total dose of remifentanil used for analgesia;Duration of invasive mechanical ventilation;ICU mortality rate; ICU length of stay;liver function indicators; | — |
Countries
China
Contacts
Public ContactLi Bin
The First Hospital of Lanzhou University
Outcome results
None listed