Gram-positive pulmonary infection
Conditions
Interventions
Steady state drug concentration determination group:The subjects were given the fifth dose and 1ml of blood was collected at each blood collection point for measuring plasma drug concentration
First dose drug concentration determination group:At each blood collection point, 1ml of blood was collected from the subjects during the first dose of medication to determine plasma drug concentratio
3h Drug concentration determination group in bronchoalveolar lavage fluid:Collect bronchoalveolar lavage fluid from subjects for determining drug concentration and urea concentration
6h Drug concentration determination group in bronchoalveolar lavage fluid:6h Collect bronchoalveolar lavage fluid from subjects for determining drug concentration and urea concentration
12h Drug concentration determination group in bronchoalveolar lavage fluid:12h Collect bronchoalveolar lavage fluid from subjects for determining drug concentration and urea concentration
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Age >=18 years; 2.Patients with lung infection caused by gram-positive bacteria; 3.According to the European Society of Critical Care Medicine (ESICM) definition of acute gastrointestinal injury (AGI) and the severity of the four-level scale, gastrointestinal function is judged as grade I and grade II patients;
Exclusion criteria
Exclusion criteria: 1.People who are allergic to oxazolidinones or have severe allergies; 2.Pregnant and lactating women; 3.It is not suitable for oral/nasal feeding/gastrointestinal nutrition tube administration, or there are gastrointestinal diseases that will seriously affect oral drug absorption; 4.Participants in other clinical trials; 5.Clinical trial participants deemed unsuitable by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First dose blood drug concentration value,Steady state blood drug concentration value;Concentration values of Contezolid in alveolar lavage fluid;Steady state blood drug concentration value;The urea concentration value in the alveolar lavage fluid; | — |
Countries
China
Contacts
Public ContactLi Yang
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed