Gastric Cancer
Conditions
Interventions
Gastric cancer patients undergoing primary surgical treatment:No intervention
Gastric cancer patients undergoing surgery following neoadjuvant therapy:No intervention
Sponsors
Xijing Hospital, Air Force Medical University (PLA)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Age at initial diagnosis: 18-75 years; 2) Histologically confirmed gastric or gastroesophageal junction malignancy, with complete medical records, confirmed pathological diagnosis, and definitive staging data (TNM staging system); 3) No history of other primary malignancies; 4) Absence of distant metastases (liver, lung, or other sites) confirmed by imaging examination (CT/MRI); 5) No prior surgical resection, chemotherapy, or PD-1/PD-L1 immunotherapy before enrollment; 6) Availability of complete biospecimen information, including: Sample ID (medical record number), Demographic data (sex, age), Clinical diagnostic data, Tumor marker profiles (CEA, CA19-9, etc.)
Exclusion criteria
Exclusion criteria: 1) Life expectancy <6 months (as assessed by ECOG score =4 or Palliative Performance Scale =30%), 2) Cognitive/psychiatric conditions: a. Legally incapacitated individuals without legal guardians, b. Active psychotic disorders (e.g., schizophrenia, bipolar disorder) or dementia (MMSE score <24), 3) Investigator-determined exclusions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Multi-gene methylation levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor Markers;Imaging Examinations; | — |
Countries
China
Contacts
Public ContactNie Yongzhan
Xijing Hospital, Air Force Medical University (PLA)
Outcome results
None listed