None
Conditions
Interventions
Experimental group:First, slowly inject 0.04-0.05mg/kg of remifentanil according to the corrected body weight, and then intravenously inject 1ug/kg of remifentanil according to the corrected body weig
Control group:First inject an equivalent dose of placebo, then slowly intravenously inject remifentanil 1ug/kg
Sponsors
Xuzhou Medical University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age range from 16 to 65 years old; (2) ASA classification II-III; (3)BMI>=30 kg/m^2; (4) Accept painless gastroscopy examination; (5) It is expected that the gastroscopy operation time will not exceed 15 minutes; (6) Those who voluntarily cooperate with this study.
Exclusion criteria
Exclusion criteria: (1) Complicated endoscopic techniques (such as cholangiopancreatography, endoscopic ultrasound, endoscopic mucosal resection, endoscopic submucosal dissection, peroral endoscopic myotomy, etc.) should be performed; (2) SpO2=180mmHg and/or diastolic blood pressure >=110mmHg after admission; (3) confirmed diagnosis of obstructive sleep apnea syndrome; (4) those who are known to be allergic to or have contraindications to opioids, benzodiazepines and their rescue drugs; (5) severe respiratory and cardiovascular diseases, liver and kidney dysfunction and coagulation dysfunction; (6) patients with mental disorders, long-term use of psychotropic drugs and cognitive impairment; (7) having a history of drug abuse, drug abuse or alcohol abuse within 2 years before the screening period; (8) taking benzodiazepines daily within one month or intermittently within the last three months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The success rate of endoscopic placement without any response (when the patient experiences dry vomiting, coughing, or body movement reaction during or within 1 minute of endoscopic placement); | — |
Secondary
| Measure | Time frame |
|---|---|
| 90%<SpO2<95% and SpO2<90% incidence rates;Additional frequency and total amount of remifentanil;Patient satisfaction;The satisfaction of endoscopists;Duration of gastroscopy examination;Wake-up time;Departure time from the recovery room; | — |
Countries
China
Contacts
Public ContactLianyi Zhang/Liu Su
Xuzhou Medical University Affiliated Hospital
Outcome results
None listed