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Hydromorphone Added to Ropivacaine for Transversus Abdominis Plane Block Improves postoperative quality of life after Radical Colorectal Cancer Surgery: A Randomized Double-Blind Trial

Hydromorphone Added to Ropivacaine for Transversus Abdominis Plane Block Improves postoperative quality of life after Radical Colorectal Cancer Surgery: A Randomized Double-Blind Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500101383
Enrollment
Unknown
Registered
2025-04-24
Start date
2025-04-30
Completion date
Unknown
Last updated
2025-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

Test group: Abdominal Transversus Plane Block Performed with Hydrocodone and Ropivacaine

Sponsors

Yibin Second People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. All participants signed the informed consent form; 2. Age range: 45 - 75 years old; 3. American Society of Anesthesiologists (ASA) classification: I - III; 4. Scheduled for laparoscopic radical resection of colorectal cancer, with operation duration >= 120 minutes; 5. Preoperative Barthel Index score >= 95 points.

Exclusion criteria

Exclusion criteria: 1. Patients with mental and psychological disorders; 2. Those with a history of long-term alcohol abuse and drug use, or those who have been taking diazepam or opioid drugs for a long time; 3. Patients whose Mini-Mental State Examination (MMSE) score before surgery determined that they already had PND (such as patients with Alzheimer's disease); 4. Those who have adverse reactions to the anesthetic drugs used; 5. Those with infection at the puncture site and abnormal coagulation function; 6. Those with diabetes and severe organ dysfunction; 7. Those who refuse to participate in any part of this study, such as those who refuse to participate in the scoring of each scale before and after surgery, or those who refuse the anesthesia plan in this study; 8. Those with severe organic lesions (coronary heart disease, second-degree or higher atrioventricular block, bradycardia (HR < 50 beats/min), hypotension (SBP < 90 mmHg), bronchial asthma, severe hypertension, severe blood system dysfunction, liver and kidney function disorders, brain dysfunction, gastric emptying disorder and gastroparesis, patients with significant electrolyte abnormalities)

Design outcomes

Primary

MeasureTime frame
Barthel index;

Secondary

MeasureTime frame
visual analogue scale;Frequency of postoperative analgesia administration;Postoperative hospital stay;postoperative nausea and vomiting;

Countries

China

Contacts

Public ContactYang Li

Yibin Second People's Hospital

568457863@qq.com+86 156 8087 4230

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026